Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 11/20 | 0.77 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.77 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.77 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.77 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.77 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.77 |
| ▸ | CDK1 | P06493 | 1/20 | 0.77 |
| ▸ | ROS1 | P08922 | 1/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.77 |
| ▸ | CDK2 | P24941 | 1/20 | 0.77 |
| ▸ | FLT3 | P36888 | 1/20 | 0.77 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.77 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.77 |
| ▸ | CLK2 | P49760 | 1/20 | 0.77 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.77 |
| ▸ | MELK | Q14680 | 1/20 | 0.77 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.77 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.77 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141963 | 1.00 | ADK (0.77) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL20142559 | 0.87 | ATG7 (0.73) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL20141857 | 0.87 | ATG7 (0.73) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL20142126 | 0.87 | ADK (1.00) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL8975866 | 0.87 | ADK (1.00) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL638908 | 0.87 | ADK (1.00) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL8975805 | 0.87 | ADK (1.00) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL638910 | 0.87 | ADK (1.00) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL20142058 | 0.86 | ATG7 (0.73) | ADKDOT1LCDK5DCLK1DAPK3 | |
| SCHEMBL22758727 | 0.86 | ATG7 (0.73) | ADKDOT1LCDK5DCLK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089786-A1 | ATG7 INHIBITORS AND THE USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |