Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.47 |
| ▸ | FASN | P49327 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156964 | 0.97 | MTOR (0.49) | MTORRPTORMLST8PPARGKDM4E | |
| SCHEMBL20139962 | 0.89 | MTOR (0.55) | MTORRPTORMLST8KDM4EGRIN2B | |
| SCHEMBL20139989 | 0.87 | MTOR (0.49) | MTORRPTORMLST8KDM4EPARP1 | |
| SCHEMBL20141050 | 0.87 | MTOR (0.46) | MTORRPTORMLST8KDM4EPARP1 | |
| SCHEMBL20140388 | 0.87 | MTOR (0.47) | MTORRPTORMLST8PPARGPARP1 | |
| SCHEMBL20156997 | 0.86 | MTOR (0.44) | MTORRPTORMLST8FASNPPARG | |
| SCHEMBL20139972 | 0.86 | MTOR (0.48) | MTORRPTORMLST8KDM4EPARP1 | |
| SCHEMBL20139934 | 0.86 | PPARG (0.47) | MTORRPTORMLST8PPARGKDM4E | |
| SCHEMBL20140246 | 0.85 | MTOR (0.57) | MTORRPTORMLST8PARP1 | |
| SCHEMBL20140719 | 0.85 | MTOR (0.57) | MTORRPTORMLST8PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |