Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156887 | 0.92 | PPARG (0.46) | PPARGMTORRPTORMLST8PARP1 | |
| SCHEMBL20157251 | 0.92 | PARP1 (0.49) | PPARGMTORRPTORMLST8PARP1 | |
| SCHEMBL20140585 | 0.90 | PPARG (0.47) | PPARGMTORRPTORMLST8PARP1 | |
| SCHEMBL20156970 | 0.90 | PRKAA2 (0.47) | MTORRPTORMLST8PARP1PRKAA2 | |
| SCHEMBL20140785 | 0.90 | PARP1 (0.47) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140697 | 0.89 | PPARA (0.49) | MTORRPTORMLST8PRKAA2RET | |
| SCHEMBL20156964 | 0.89 | MTOR (0.49) | PPARGMTORRPTORMLST8PARP1 | |
| SCHEMBL20140044 | 0.88 | MTOR (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140587 | 0.87 | MTOR (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20141182 | 0.87 | PARP1 (0.48) | MTORRPTORMLST8PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |