Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.42 |
| ▸ | FASN | P49327 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156964 | 0.89 | MTOR (0.49) | MTORRPTORMLST8PRKAA2PPARG | |
| SCHEMBL20141367 | 0.88 | RET (0.42) | DRD4RET | |
| SCHEMBL20141707 | 0.86 | MTOR (0.47) | MTORRPTORMLST8PRKAA2FASN | |
| SCHEMBL20140057 | 0.82 | MTOR (0.51) | MTORRPTORMLST8FASNDRD4 | |
| SCHEMBL20157050 | 0.82 | MTOR (0.55) | MTORRPTORMLST8FASNKDM4E | |
| SCHEMBL20139878 | 0.81 | PRKAA2 (0.43) | MTORRPTORMLST8PRKAA2PPARG | |
| SCHEMBL20139989 | 0.79 | MTOR (0.49) | MTORRPTORMLST8DRD4PARP1 | |
| SCHEMBL20140070 | 0.79 | MTOR (0.47) | MTORRPTORMLST8PPARGPARP1 | |
| SCHEMBL20140046 | 0.79 | MTOR (0.47) | MTORRPTORMLST8PPARGPARP1 | |
| SCHEMBL20140048 | 0.79 | MTOR (0.47) | MTORRPTORMLST8PPARGPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |