Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716286 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL1314087 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL16699599 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL18187532 | 0.87 | ALDH1A1 (0.45) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL4712694 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL16682690 | 0.85 | DRD2 (0.47) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL16682537 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBTDP1MAPTRAB9A | |
| SCHEMBL4760588 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL16682532 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL4714499 | 0.84 | MAPT (0.57) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |