Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29676683 | 0.90 | DRD2 (0.46) | DRD2KMT2AALDH1A1PRMT5WDR77 | |
| SCHEMBL12953718 | 0.84 | ALDH1A1 (0.47) | DRD2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5862011 | 0.84 | KMT2A (0.61) | KMT2AMEN1ALDH1A1PRMT5WDR77 | |
| SCHEMBL31108108 | 0.83 | CARM1 (0.49) | DRD2KMT2AMEN1ALDH1A1PRMT5 | |
| SCHEMBL1015138 | 0.83 | CARM1 (0.49) | DRD2KMT2AMEN1ALDH1A1PRMT5 | |
| SCHEMBL12952775 | 0.83 | ESR2 (0.46) | DRD2KMT2AMEN1ALDH1A1PRMT5 | |
| SCHEMBL23810739 | 0.82 | CARM1 (0.50) | DRD2 | |
| SCHEMBL30955054 | 0.82 | CARM1 (0.50) | DRD2ALDH1A1PRMT5WDR77 | |
| SCHEMBL12984530 | 0.82 | KCNQ2 (0.41) | DRD2KMT2AMEN1ALDH1A1PRMT5 | |
| SCHEMBL23348748 | 0.82 | CARM1 (0.50) | DRD2ALDH1A1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |