Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.51 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.51 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129661 | 1.00 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL20141349 | 0.86 | SMO (0.45) | SMOGRM1 | |
| SCHEMBL21360402 | 0.82 | POLB (0.53) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL20133687 | 0.80 | POLB (0.49) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL15024213 | 0.80 | GPR119 (0.61) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL20129733 | 0.79 | GPR119 (0.50) | GPR119CHRNA7GRM1 | |
| SCHEMBL20129601 | 0.78 | GPR119 (0.60) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL240797 | 0.78 | GPR119 (0.50) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL20129618 | 0.78 | GPR119 (0.60) | SMARCA2SMARCA4PBRM1GPR119POLB | |
| SCHEMBL4319554 | 0.78 | GPR119 (0.50) | SMARCA2SMARCA4PBRM1GPR119POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |