Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156810 | 0.94 | MTOR (0.47) | GRM1PARP1TNK2TNK1DRD2 | |
| SCHEMBL20157309 | 0.94 | MTOR (0.47) | GRM1PARP1TNK2TNK1DRD2 | |
| SCHEMBL20142175 | 0.91 | GRM1 (0.50) | GRM1DRD2KDM4EALDH1A1HTR2A | |
| SCHEMBL20157005 | 0.89 | CHRM4 (0.47) | GRM1KDM4EALDH1A1MTORRPTOR | |
| SCHEMBL20157004 | 0.89 | CHRM4 (0.47) | GRM1KDM4EALDH1A1MTORRPTOR | |
| SCHEMBL20140106 | 0.88 | GRM1 (0.47) | GRM1PARP1TNK2TNK1KDM4E | |
| SCHEMBL20157186 | 0.87 | MTOR (0.55) | GRM1DRD2KDM4EALDH1A1MTOR | |
| SCHEMBL20157188 | 0.87 | MTOR (0.55) | GRM1DRD2KDM4EALDH1A1MTOR | |
| SCHEMBL20140600 | 0.87 | KDM4E (0.54) | PARP1TNK2TNK1DRD2KDM4E | |
| SCHEMBL20157075 | 0.86 | CHRM4 (0.49) | GRM1MTORRPTORMLST8CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |