Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | MTOR | P42345 | 4/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.49 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.47 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140664 | 0.93 | MTOR (0.57) | KDM4EALDH1A1TDP1PARP1DRD2 | |
| SCHEMBL20140044 | 0.91 | MTOR (0.54) | KDM4EALDH1A1PARP1DRD2MTOR | |
| SCHEMBL20157539 | 0.89 | MTOR (0.46) | KDM4EALDH1A1PARP1MTORRPTOR | |
| SCHEMBL20142065 | 0.88 | KDM4E (0.51) | KDM4EALDH1A1TDP1PARP1DRD2 | |
| SCHEMBL20156994 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1TDP1PARP1DRD2 | |
| SCHEMBL20140323 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1TDP1PARP1DRD2 | |
| SCHEMBL20141295 | 0.88 | KDM4E (0.50) | KDM4EALDH1A1TDP1PARP1DRD2 | |
| SCHEMBL20140262 | 0.87 | KDM4E (0.49) | KDM4EALDH1A1TDP1PARP1MTOR | |
| SCHEMBL20141840 | 0.87 | GRM1 (0.49) | KDM4EALDH1A1TDP1PARP1DRD2 | |
| SCHEMBL20156931 | 0.86 | MTOR (0.51) | KDM4EALDH1A1PARP1DRD2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |