Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142461 | 0.89 | MEN1 (0.59) | GSK3AGSK3BMEN1KMT2ANPC1 | |
| SCHEMBL20142452 | 0.88 | NPC1 (0.50) | GSK3AGSK3BMEN1KMT2ANPC1 | |
| SCHEMBL20142465 | 0.86 | CDK5 (0.52) | MEN1KMT2ANPC1CCNA2CDK2 | |
| SCHEMBL20142129 | 0.85 | GSK3A (0.71) | GSK3AGSK3BMEN1KMT2ANPC1 | |
| SCHEMBL20142448 | 0.85 | GSK3A (0.73) | GSK3AGSK3BMEN1KMT2ANPC1 | |
| SCHEMBL20142848 | 0.82 | GSK3A (0.58) | GSK3AGSK3BMEN1KMT2ANPC1 | |
| SCHEMBL20142498 | 0.81 | CCNA2 (0.52) | MEN1KMT2ANPC1CCNA2CDK2 | |
| SCHEMBL20142401 | 0.81 | GSK3A (0.58) | GSK3AGSK3BMEN1KMT2ANPC1 | |
| SCHEMBL20142189 | 0.80 | CCNA2 (0.52) | CCNA2CDK2ADORA3ADORA2AADORA1 | |
| SCHEMBL20142510 | 0.78 | ZAP70 (0.55) | GSK3AGSK3BMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |