Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 7/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156842 | 0.89 | DRD4 (0.39) | DRD4DRD3RETDRD2KDM4E | |
| SCHEMBL20156840 | 0.88 | RET (0.39) | DRD4DRD3RETDRD2KDM4E | |
| SCHEMBL20156839 | 0.87 | RET (0.37) | DRD4DRD3RETDRD2KDM4E | |
| SCHEMBL20142054 | 0.86 | MTOR (0.45) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20156841 | 0.80 | DRD4 (0.51) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20141633 | 0.80 | DRD4 (0.46) | DRD4DRD3RETALDH1A1 | |
| SCHEMBL20141994 | 0.79 | DRD4 (0.44) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20139961 | 0.78 | DRD4 (0.45) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20140742 | 0.76 | DRD4 (0.44) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20139927 | 0.69 | DRD4 (0.53) | DRD4DRD3DRD2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |