Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156842 | 0.91 | DRD4 (0.39) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20141996 | 0.86 | DRD4 (0.46) | DRD4DRD2DRD3THRBALDH1A1 | |
| SCHEMBL20156840 | 0.85 | RET (0.39) | DRD4DRD2DRD3THRBALDH1A1 | |
| SCHEMBL20156839 | 0.84 | RET (0.37) | DRD4DRD2DRD3THRBALDH1A1 | |
| SCHEMBL20156795 | 0.82 | MTOR (0.49) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20156796 | 0.82 | MTOR (0.47) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20157437 | 0.80 | MTOR (0.45) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20142053 | 0.80 | MTOR (0.43) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20140042 | 0.80 | DRD2 (0.51) | MTORRPTORMLST8DRD4DRD2 | |
| Trifluoroacetic Acid SCHEMBL20140050 | 0.79 | MTOR (0.46) | MTORRPTORMLST8NAMPTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |