Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GOT1 | P17174 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142004 | 1.00 | MTOR (0.47) | MTORRPTORMLST8GAAMAPT | |
| SCHEMBL20141016 | 0.90 | MTOR (0.53) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20156943 | 0.88 | GAA (0.49) | MTORRPTORMLST8GAAMAPT | |
| SCHEMBL20156947 | 0.87 | MTOR (0.45) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156829 | 0.87 | MTOR (0.43) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20141846 | 0.86 | MTOR (0.59) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20156832 | 0.86 | MTOR (0.59) | MTORRPTORMLST8DRD2DRD3 | |
| Trifluoroacetic Acid SCHEMBL20140975 | 0.83 | CHRM4 (0.42) | MTORRPTORMLST8CHRM4 | |
| Trifluoroacetic Acid SCHEMBL20140974 | 0.83 | CHRM4 (0.42) | MTORRPTORMLST8CHRM4 | |
| Trifluoroacetic Acid SCHEMBL20141710 | 0.83 | MTOR (0.43) | MTORRPTORMLST8CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |