Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.77 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.77 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.77 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142656 | 1.00 | MTOR (0.77) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20159013 | 0.93 | MTOR (0.80) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20159154 | 0.89 | MTOR (0.72) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20159093 | 0.88 | MTOR (0.68) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20139536 | 0.87 | MTOR (1.00) | MTORRPTORMLST8CHRM2CHRM4 | |
| SCHEMBL20139537 | 0.87 | MTOR (1.00) | MTORRPTORMLST8CHRM2CHRM4 | |
| SCHEMBL20159012 | 0.86 | MTOR (0.72) | MTORRPTORMLST8CHRM2CHRM4 | |
| SCHEMBL20140568 | 0.86 | MTOR (0.58) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140565 | 0.86 | MTOR (0.58) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20159113 | 0.85 | MTOR (0.73) | MTORRPTORMLST8CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |