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SCHEMBL20142791

SCHEMBL20142791

Cc1cc(C)c(C(=O)N2CCN(c3ccccc3)[C@H](CO)C2)c(C)c1NC1CCN(c2ccncn2)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 5/20 0.61
▸ RPTOR Q8N122 5/20 0.61
▸ MLST8 Q9BVC4 5/20 0.61
▸ GPR119 Q8TDV5 1/20 0.35
▸ RIPK1 Q13546 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ DPP4 P27487 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ DPP8 Q6V1X1 1/20 0.34
▸ DPP9 Q86TI2 1/20 0.34
▸ CCNC P24863 1/20 0.34
▸ CDK8 P49336 1/20 0.34
▸ F10 P00742 1/20 0.34
▸ CHRM4 P08173 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ MC4R P32245 1/20 0.34
▸ MC3R P41968 1/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21360354 0.87 MTOR (0.77) MTORRPTORMLST8KCNH2CHRM4
SCHEMBL21360334 0.87 MTOR (0.77) MTORRPTORMLST8KCNH2
SCHEMBL22187060 0.86 MTOR (0.53) MTORRPTORMLST8GPR119RIPK1
SCHEMBL22693124 0.86 MTOR (0.72) MTORRPTORMLST8POLBMEN1
SCHEMBL20142829 0.85 MTOR (0.56) MTORRPTORMLST8ALDH1A1KDM5A
SCHEMBL22693247 0.84 MTOR (0.59) MTORRPTORMLST8CHRM4
SCHEMBL20140999 0.83 MTOR (0.54) MTORRPTORMLST8KMT2A
SCHEMBL21360296 0.82 MTOR (0.69) MTORRPTORMLST8POLBKMT2A
SCHEMBL21360308 0.82 MTOR (0.78) MTORRPTORMLST8KCNH2POLB
SCHEMBL21360408 0.81 MTOR (0.67) MTORRPTORMLST8CYP2D6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.