Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.56 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 6/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140999 | 0.91 | MTOR (0.54) | MTORRPTORMLST8SPRRORC | |
| SCHEMBL20141406 | 0.88 | MTOR (0.51) | MTORRPTORMLST8NPSR1USP2 | |
| SCHEMBL20141279 | 0.86 | MTOR (0.67) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL21360408 | 0.86 | MTOR (0.67) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL21360419 | 0.86 | MTOR (0.50) | MTORRPTORMLST8SPRRORC | |
| SCHEMBL21360334 | 0.85 | MTOR (0.77) | MTORRPTORMLST8 | |
| SCHEMBL20142791 | 0.85 | MTOR (0.61) | MTORRPTORMLST8KDM5AALDH1A1 | |
| SCHEMBL21360354 | 0.84 | MTOR (0.77) | MTORRPTORMLST8CCNKCCNA2 | |
| SCHEMBL22693247 | 0.84 | MTOR (0.59) | MTORRPTORMLST8 | |
| SCHEMBL22693124 | 0.80 | MTOR (0.72) | MTORRPTORMLST8KDM5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |