Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12629076 | 1.00 | FKBP1A (0.51) | FKBP1AGAAATMTDP1KMT2A | |
| SCHEMBL12629077 | 0.92 | FKBP1A (0.60) | FKBP1AGAAKMT2AEPHX2MEN1 | |
| SCHEMBL2012296 | 0.92 | FKBP1A (0.60) | FKBP1AGAAKMT2AEPHX2MEN1 | |
| SCHEMBL2013886 | 0.91 | FKBP1A (0.51) | FKBP1AGAAKMT2AMEN1POLB | |
| SCHEMBL12628519 | 0.91 | FKBP1A (0.51) | FKBP1AGAAKMT2AMEN1POLB | |
| SCHEMBL12629079 | 0.91 | ALDH1A1 (0.53) | FKBP1AGAAKMT2AEPHX2MEN1 | |
| SCHEMBL2014843 | 0.89 | ALDH1A1 (0.52) | KMT2AMEN1POLB | |
| SCHEMBL12629083 | 0.89 | ALDH1A1 (0.52) | KMT2AMEN1POLB | |
| SCHEMBL12628507 | 0.85 | FKBP1A (0.52) | FKBP1AGAAKMT2AMEN1 | |
| SCHEMBL2012909 | 0.85 | FKBP1A (0.52) | FKBP1AGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | claimed |