SCHEMBL2014282

SCHEMBL2014282

COC(=O)Nc1ccco1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.50
KDM4E B2RXH2 2/20 0.50
KDM4C Q9H3R0 1/20 0.46
KMT2A Q03164 3/20 0.44
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
TP53 P04637 1/20 0.41
HPGD P15428 2/20 0.41
MAPK1 P28482 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
PSMD14 O00487 1/20 0.40
CACNA1B Q00975 1/20 0.40
APBA1 Q02410 1/20 0.40
TSHR P16473 1/20 0.39
CASP1 P29466 1/20 0.39
HSD17B10 Q99714 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28983970 0.93 KDM4E (0.46) SMN1; SMN2KDM4EKDM4CKMT2ACES2
SCHEMBL1258860 0.82 HPGD (0.50) SMN1; SMN2KDM4EALDH1A1NPC1RAB9A
SCHEMBL5124451 0.82 SMN1; SMN2 (0.52) SMN1; SMN2KDM4EKDM4CKMT2AALDH1A1
SCHEMBL12191262 0.79
SCHEMBL9547521 0.79 SMN1; SMN2 (0.56) SMN1; SMN2KDM4CKMT2ACES2CES1
SCHEMBL3483318 0.77
SCHEMBL28883729 0.75 SMN1; SMN2 (0.43) SMN1; SMN2KDM4EKDM4CALDH1A1NPC1
SCHEMBL11765049 0.75
SCHEMBL12822285 0.74 RAB9A (0.57) SMN1; SMN2KDM4CKMT2AALDH1A1NPC1
SCHEMBL29364207 0.74 SMN1; SMN2 (0.49) SMN1; SMN2KDM4CKMT2ACES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118126441-A Damping EVA foaming material for picocell racket 合肥市尚技体育用品有限公司 2024-06-04 CN claimed
CN-109898342-B Preparation method of scratch-resistant synthetic leather based on high-resilience waterborne polyurethane 四川大学 2021-08-27 CN claimed
CN-105209449-B Inhibitors of the kynurenine pathway 库拉德夫制药私人有限公司 2019-02-01 CN claimed
CN-119056460-A Method for catalytic synthesis of bio-based furfuryl carbamate 丽水学院 2024-12-03 CN disclosed
CN-110105434-B Stapled and stitched polypeptides and uses thereof 哈佛大学的校长及成员们 2024-09-17 CN disclosed
CN-113710660-B DOT1L degradation agent and application thereof 达纳-法伯癌症研究公司 2024-07-02 CN disclosed
CN-114736219-B Antitumor compounds 法马马有限公司 2024-06-07 CN disclosed
CN-114751920-B Antitumor compounds 法马马有限公司 2024-06-07 CN disclosed
CN-118126441-A Damping EVA foaming material for picocell racket 合肥市尚技体育用品有限公司 2024-06-04 CN disclosed
CN-118076584-A Esters of retinoids and bakuchiol and formulations thereof 康纳根有限公司 2024-05-24 CN disclosed
CN-118059096-A Methods of treating CNS disorders 杭州高光制药有限公司 2024-05-24 CN disclosed
EP-2513200-A1 A BIOMATERIAL Vysera Biomedical Limited (IE) 2012-10-24 EP disclosed
EP-2512386-A1 A GASTROINTESTINAL IMPLANT DEVICE Vysera Biomedical Limited (IE) 2012-10-24 EP disclosed
CN-102711473-A Bruton's tyrosine kinase inhibitors BIOGEN IDEC INC 2012-10-03 CN disclosed
CN-102159203-A Activation of histone deacetylase 1(HDAC1) protects against DNA damage and increases neuronal survival MASSACHUSETTS INST TECHNOLOGY 2011-08-17 CN disclosed
WO-2011073970-A1 A GASTROINTESTINAL IMPLANT DEVICE VYSERA BIOMEDICAL LIMITED (IE) 2011-06-23 WO disclosed
WO-2011073967-A1 A BIOMATERIAL VYSERA BIOMEDICAL LIMITED (IE) 2011-06-23 WO disclosed
CN-101932592-A Antineoplastic compound PHARMA MAR SA 2010-12-29 CN disclosed
CN-101547689-A Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use ERIMOS PHARMACEUTICALS LLC (US) 2009-09-30 CN disclosed
CN-101010336-A Peptide antibiotics and process for preparing same BIOSOURCE PHARM INC (US) 2007-08-01 CN disclosed