Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159203 | 0.95 | PDE4D (0.44) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20159509 | 0.91 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20159107 | 0.91 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20138995 | 0.86 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20142942 | 0.81 | PDE4A (0.44) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20142920 | 0.80 | CYP19A1 (0.45) | CYP19A1MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL20159426 | 0.78 | CYP19A1 (0.38) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20142916 | 0.78 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DKCNH2 | |
| SCHEMBL20138839 | 0.76 | CYP19A1 (0.39) | PDE4BCYP19A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL20159211 | 0.74 | SMN1; SMN2 (0.40) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |