Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142960 | 0.84 | SMN1; SMN2 (0.41) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL20138839 | 0.81 | CYP19A1 (0.39) | CYP19A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL20138842 | 0.80 | PDE4B (0.40) | CYP19A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL20142933 | 0.80 | PDE4B (0.45) | CYP19A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL20159211 | 0.79 | SMN1; SMN2 (0.40) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL20159716 | 0.78 | PDE4B (0.36) | CYP19A1MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL20159426 | 0.77 | CYP19A1 (0.38) | CYP19A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL20159203 | 0.77 | PDE4D (0.44) | CYP19A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL20159509 | 0.77 | PDE4B (0.46) | CYP19A1SMN1; SMN2 | |
| SCHEMBL20159396 | 0.76 | HRH3 (0.36) | CYP19A1MEN1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |