Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138653 | 0.86 | GAA (0.48) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20159752 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20142920 | 0.79 | CYP19A1 (0.45) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20138839 | 0.75 | CYP19A1 (0.39) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6014950 | 0.75 | MAPT (0.42) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20142933 | 0.74 | PDE4B (0.45) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL20159203 | 0.72 | PDE4D (0.44) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL20159426 | 0.72 | CYP19A1 (0.38) | MEN1KMT2AL3MBTL1PDE4APDE4B | |
| SCHEMBL20138842 | 0.72 | PDE4B (0.40) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20159207 | 0.72 | MEN1 (0.41) | SMN1; SMN2MEN1KMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |