Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180665 | 0.87 | GSK3B (0.53) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL8531622 | 0.82 | MAPT (0.52) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10021821 | 0.82 | GSK3B (0.57) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL28303452 | 0.82 | GSK3B (0.48) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL20530433 | 0.81 | GSK3B (0.50) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL8534141 | 0.80 | MAPT (0.59) | GSK3BHAO1NPC1HPGDRAB9A | |
| SCHEMBL20159373 | 0.80 | ALDH1A1 (0.50) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1748168 | 0.76 | GSK3B (0.46) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1748024 | 0.75 | GSK3B (0.48) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10645626 | 0.75 | HDAC1 (0.42) | GSK3BHDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |