Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22923512 | 0.83 | MIF (0.44) | MAPT | |
| SCHEMBL22923793 | 0.82 | MIF (0.34) | TP53MAPTPDE4BTHRBMEN1 | |
| SCHEMBL20138842 | 0.81 | PDE4B (0.40) | TP53LMNAMAPTPDE4BMEN1 | |
| SCHEMBL20159528 | 0.80 | PDE4B (0.40) | PDE4BMEN1KMT2A | |
| SCHEMBL20159716 | 0.79 | PDE4B (0.36) | LMNAPDE4BMEN1KMT2A | |
| SCHEMBL20138839 | 0.77 | CYP19A1 (0.39) | LMNAPDE4BMEN1KMT2A | |
| SCHEMBL20159539 | 0.75 | HRH3 (0.36) | CD274 | |
| SCHEMBL20159426 | 0.74 | CYP19A1 (0.38) | PDE4BMEN1KMT2A | |
| SCHEMBL20159516 | 0.73 | PDE4B (0.34) | PDE4BMEN1KMT2A | |
| SCHEMBL20159396 | 0.73 | HRH3 (0.36) | PDE4BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |