Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | REN | P00797 | 9/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159716 | 0.93 | PDE4B (0.36) | PDE4BKCNH2HRH3CYP19A1MEN1 | |
| SCHEMBL20159532 | 0.88 | SMN1; SMN2 (0.41) | PDE4BRENCYP2D6CYP2C9KCNH2 | |
| SCHEMBL20138842 | 0.83 | PDE4B (0.40) | PDE4BCYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL20138839 | 0.81 | CYP19A1 (0.39) | PDE4BCYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL20138895 | 0.81 | SMN1; SMN2 (0.43) | PDE4BKCNH2HRH3MEN1KMT2A | |
| SCHEMBL20142970 | 0.80 | TP53 (0.36) | PDE4BMEN1KMT2A | |
| SCHEMBL20159539 | 0.79 | HRH3 (0.36) | CYP2D6HRH3CYP19A1ALDH1A1 | |
| SCHEMBL20159426 | 0.78 | CYP19A1 (0.38) | PDE4BKCNH2HRH3CYP19A1MEN1 | |
| SCHEMBL20159396 | 0.77 | HRH3 (0.36) | PDE4BCYP2C9HRH3CYP19A1MEN1 | |
| SCHEMBL20159516 | 0.77 | PDE4B (0.34) | PDE4BCYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |