Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159360 | 0.87 | NPC1 (0.44) | HRH3L3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL20138839 | 0.84 | CYP19A1 (0.39) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL20159516 | 0.82 | PDE4B (0.34) | L3MBTL1MEN1KMT2ACYP19A1PDE4B | |
| SCHEMBL20138842 | 0.81 | PDE4B (0.40) | L3MBTL1MEN1KMT2ASMN1; SMN2CYP19A1 | |
| SCHEMBL20159426 | 0.81 | CYP19A1 (0.38) | HRH3L3MBTL1MEN1KMT2ACYP19A1 | |
| SCHEMBL20159716 | 0.79 | PDE4B (0.36) | HRH3L3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL20159539 | 0.77 | HRH3 (0.36) | HRH3CYP19A1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL20159528 | 0.77 | PDE4B (0.40) | HRH3MEN1KMT2ACYP19A1ALDH1A1 | |
| SCHEMBL20142920 | 0.76 | CYP19A1 (0.45) | L3MBTL1MEN1KMT2ASMN1; SMN2CYP19A1 | |
| SCHEMBL20142970 | 0.73 | TP53 (0.36) | MEN1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |