Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.41 |
| ▸ | CASK | O14936 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.41 |
| ▸ | CDK14 | O94921 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | MAK | P20794 | 1/20 | 0.41 |
| ▸ | CDK11B | P21127 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142977 | 0.81 | HPGD (0.50) | HPGDP2RX7 | |
| SCHEMBL20142976 | 0.81 | HPGD (0.50) | HPGDP2RX7 | |
| SCHEMBL23185459 | 0.78 | PLK4 (0.50) | CDK2CCNA1PTGESBRD4P2RX7 | |
| SCHEMBL20139011 | 0.78 | LMNA (0.52) | HPGDP2RX7GSK3AGSK3B | |
| SCHEMBL20139008 | 0.78 | LMNA (0.52) | HPGDP2RX7GSK3AGSK3B | |
| SCHEMBL20142932 | 0.77 | HPGD (0.48) | HPGDALOX15CLK4POLB | |
| SCHEMBL20138798 | 0.77 | HPGD (0.51) | HPGDPTGESP2RX7POLB | |
| SCHEMBL20142934 | 0.77 | HPGD (0.48) | HPGDALOX15CLK4POLB | |
| SCHEMBL20138796 | 0.77 | HPGD (0.51) | HPGDPTGESP2RX7POLB | |
| SCHEMBL18216438 | 0.76 | HPGD (0.55) | HPGDALOX15GSK3AGSK3BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |