Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 2/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142976 | 1.00 | HPGD (0.50) | HPGDKDRMEN1KMT2APDE4B | |
| SCHEMBL20161124 | 0.89 | HPGD (0.47) | HPGDMEN1KMT2APDE4BGRM4 | |
| SCHEMBL20139008 | 0.89 | LMNA (0.52) | HPGDKMT2APDE4BGRM4P2RX7 | |
| SCHEMBL20139011 | 0.89 | LMNA (0.52) | HPGDKMT2APDE4BGRM4P2RX7 | |
| SCHEMBL20138815 | 0.84 | GSK3A (0.51) | HPGDKDRMEN1KMT2AP2RX7 | |
| SCHEMBL20138814 | 0.84 | GSK3A (0.51) | HPGDKDRMEN1KMT2AP2RX7 | |
| SCHEMBL20142963 | 0.83 | HPGD (0.46) | HPGDPDE4BGRM4MAPTABL1 | |
| SCHEMBL20142964 | 0.83 | HPGD (0.46) | HPGDPDE4BGRM4MAPTABL1 | |
| SCHEMBL20142974 | 0.81 | HPGD (0.48) | HPGDP2RX7 | |
| SCHEMBL20143016 | 0.80 | HPGD (0.49) | HPGDMEN1KMT2APDE4BGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |