Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249982 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL2435532 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL7597398 | 0.74 | ALDH1A1 (0.65) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL6997297 | 0.69 | KDM4E (0.61) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL2576924 | 0.67 | KDM4E (0.53) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL6994140 | 0.67 | KDM4E (0.59) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL2580166 | 0.67 | ALDH1A1 (0.53) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL1399942 | 0.67 | ALDH1A1 (0.55) | ALDH1A1KDM4ENPC1LMNATSHR | |
| SCHEMBL4497673 | 0.66 | ALDH1A1 (0.57) | ALDH1A1KDM4ENPC1ALOX15LMNA | |
| SCHEMBL7598991 | 0.66 | ALDH1A1 (0.68) | ALDH1A1KDM4ENPC1ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969752-B2 | Inhibitors of HIF prolyl hydroxylase | MERCK SHARP & DOHME CORP. (US) | 2018-05-15 | — | — | US | disclosed |