SCHEMBL2014331

SCHEMBL2014331

COCCCn1c(O)cc(C)c(C#N)c1=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 13/20 0.50
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
MAPT P10636 4/20 0.50
USP2 O75604 1/20 0.49
LMNA P02545 3/20 0.48
HPGD P15428 1/20 0.43
ALDH1A1 P00352 5/20 0.43
THRB P10828 1/20 0.42
HSD17B10 Q99714 3/20 0.41
MAPK1 P28482 1/20 0.41
TSHR P16473 1/20 0.40
RAB9A P51151 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GLA P06280 1/20 0.40
POLB P06746 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
GAA P10253 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28551151 0.96 KDM4E (0.49) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL29290755 0.95 KDM4E (0.46) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL5365762 0.91 KDM4E (0.51) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL10766144 0.88 KDM4E (0.57) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL10769714 0.88 KDM4E (0.57) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL10768477 0.86 KDM4E (0.56) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL11133471 0.86 KDM4E (0.50) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL6244194 0.85 KDM4E (0.49) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL11200329 0.85 KDM4E (0.52) KDM4EMEN1KMT2AMAPTUSP2
SCHEMBL11132533 0.85 KDM4E (0.52) KDM4EMEN1KMT2AMAPTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170015829-A1 Novel Pyridone Dyes CLARIANT INTERNATIONAL LTD. (CH) 2017-01-19 US disclosed
US-20170018599-A1 Pyridone Dye Composition CLARIANT INTERNATIONAL LTD. (CH) 2017-01-19 US disclosed
US-20170018599-A1 Pyridone Dye Composition CLARIANT INTERNATIONAL LTD. (CH) 2017-01-19 US disclosed
US-20170015829-A1 Novel Pyridone Dyes CLARIANT INTERNATIONAL LTD. (CH) 2017-01-19 US disclosed
WO-2015135633-A1 NOVEL PYRIDONE DYES CLARIANT INTERNATIONAL LTD (CH) 2015-09-17 WO disclosed
WO-2015135634-A1 PYRIDONE DYE COMPOSITION CLARIANT INTERNATIONAL LTD (CH) 2015-09-17 WO disclosed
EP-2513229-B1 DISPERSE AZO DYES, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF HUNTSMAN ADV MAT SWITZERLAND (CH) 2014-04-23 EP disclosed
EP-2513229-A1 DISPERSE AZO DYES, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF Huntsman Advanced Materials (Switzerland) GmbH (CH) 2012-10-24 EP disclosed
WO-2011072966-A1 DISPERSE AZO DYES, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF HUNSTSMAN ADVANCED MATERIALS (SWITZERLAND) GMBH (CH) 2011-06-23 WO disclosed
US-20090074373-A1 OPTICAL FILTER KYOWA HAKKO CHEMICAL CO., LTD. (JP) 2009-03-19 US disclosed
US-4626590-A Reactive monoazo and disazo pyridone dyestuffs containing a halo-substituted 6-member nitrogen-containing heterocyclic ring MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1986-12-02 US disclosed
EP-0040582-B1 AZO COMPOUNDS CIBA-GEIGY AG (CH) 1985-03-20 EP disclosed
EP-0109527-A1 Water-insoluble monoazo dyestuffs, methods for their preparation and their use CASSELLA Aktiengesellschaft (DE) 1984-05-30 EP disclosed
EP-0040582-A2 Azo compounds CIBA-GEIGY AG (CH) 1981-11-25 EP disclosed
US-4247456-A Water-insoluble monoazo pyridone dye CASSELLA AKTIENGESELLSCHAFT (DE) 1981-01-27 US disclosed
US-4225491-A REACTIVE DYES FOR COTTON ICI UNITED STATES, INC. (US) 1980-09-30 US disclosed
US-4140684-A FOR POLYESTERS, POLYAMIDES, AND CELLULOSE ACETATES FIDELITY UNION TRUST COMPANY, EXECUTIVE TRUSTEE UNDER THE SANDOZ TRUST (US) 1979-02-20 US disclosed
US-4118384-A DIAZOTIZATION BAYER AKTIENGESELLSCHAFT (DE) 1978-10-03 US disclosed
US-4097475-A FOR POLYESTERS AND BLENDS WITH CELLULOSE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-06-27 US disclosed
US-3957749-A WATER-INSOLUBLE MONOAZO PYRIDINE DYES CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090074373-A1 OPTICAL FILTER SRSF7, C5, SF3B5 KDM4E 1767/4885MEN1 3328/4885KMT2A 2104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.