Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21507384 | 0.82 | IRAK4 (0.40) | IRAK4KCNH2 | |
| SCHEMBL21290423 | 0.82 | IRAK4 (0.40) | IRAK4KCNH2 | |
| SCHEMBL18084625 | 0.82 | IRAK4 (0.40) | IRAK4KCNH2 | |
| SCHEMBL22354600 | 0.73 | IRAK4 (0.42) | IRAK4KCNH2 | |
| SCHEMBL5994524 | 0.73 | IRAK4 (0.42) | IRAK4KCNH2 | |
| SCHEMBL5215585 | 0.71 | LMNA (0.39) | IRAK4KCNH2 | |
| SCHEMBL9865626 | 0.71 | LMNA (0.39) | IRAK4KCNH2 | |
| SCHEMBL22259093 | 0.68 | IRAK4 (0.34) | IRAK4KCNH2 | |
| SCHEMBL9851971 | 0.65 | IRAK4 (0.38) | IRAK4KCNH2 | |
| SCHEMBL9851963 | 0.65 | IRAK4 (0.38) | IRAK4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969694-B2 | N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2018-05-15 | — | — | US | disclosed |