Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | STK25 | O00506 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144350 | 0.97 | HDAC6 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20144320 | 0.92 | HDAC3 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20144317 | 0.89 | HDAC6 (0.44) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20144341 | 0.89 | HDAC6 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20144361 | 0.81 | HDAC6 (0.46) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15442343 | 0.78 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15443391 | 0.77 | HDAC6 (0.46) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15443360 | 0.75 | HDAC6 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15598296 | 0.74 | HDAC6 (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15442340 | 0.74 | HDAC6 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186247-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2880038-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2018-05-16 | — | — | EP | disclosed |