Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144341 | 0.92 | HDAC6 (0.47) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20144317 | 0.89 | HDAC6 (0.44) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20144320 | 0.89 | HDAC3 (0.45) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20144350 | 0.81 | HDAC6 (0.45) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20144335 | 0.81 | HDAC3 (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15442505 | 0.78 | HDAC6 (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15442512 | 0.72 | FGFR1 (0.57) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15442177 | 0.72 | ABL1 (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15443033 | 0.72 | HDAC6 (0.44) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15442319 | 0.72 | HDAC3 (0.45) | HDAC6HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186247-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2880038-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2018-05-16 | — | — | EP | disclosed |