Sugi Predict

Sugi Predict / Compounds / SCHEMBL201444

SCHEMBL201444

SCHEMBL201444

O=S(=O)(OC1=CCCCC1)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HDAC4 P56524 1/20 0.32
▸ HDAC2 Q92769 1/20 0.32
▸ HDAC8 Q9BY41 1/20 0.32
▸ HDAC6 Q9UBN7 1/20 0.32
▸ BACE1 P56817 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.30
▸ ALOX15 P16050 1/20 0.30
▸ CA2 P00918 1/20 0.30
▸ DRD2 P14416 1/20 0.30
▸ DRD1 P21728 1/20 0.30
▸ DRD4 P21917 1/20 0.30
▸ DRD5 P21918 1/20 0.30
▸ DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12192210 0.98 BACE1 (0.31) HDAC4HDAC2HDAC8HDAC6BACE1
SCHEMBL5830 0.98 BACE1 (0.31) HDAC4HDAC2HDAC8HDAC6BACE1
SCHEMBL16081682 0.98 BACE1 (0.31) HDAC4HDAC2HDAC8HDAC6BACE1
SCHEMBL202259 0.94 BACE1 (0.32) BACE1DRD2DRD1DRD4DRD5
SCHEMBL15214822 0.91 HDAC4 (0.30) HDAC4HDAC2HDAC8HDAC6
SCHEMBL12581509 0.87 — —
SCHEMBL15807044 0.87 — —
SCHEMBL12893294 0.84 BACE1 (0.33) BACE1CA2DRD2DRD1DRD4
Formic Acid Methyl Ester SCHEMBL29203565 0.84 — —
SCHEMBL14606200 0.83 HDAC4 (0.32) HDAC4HDAC2HDAC8HDAC6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 298 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3004120-B1 SPIRO-1,1'-BIINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALLADIUM-CATALYZED ASYMMETRIC HECK REACTION UNIV NANYANG TECH (SG) 2018-08-29 — — EP claimed
US-20160136629-A1 SPIRO-1,1'-BINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALADIUM-CATALYZED ASYMMETRIC HECK REACTION NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-05-19 — — US claimed
EP-3004120-A1 SPIRO-1,1'-BIINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALLADIUM-CATALYZED ASYMMETRIC HECK REACTION Nanyang Technological University (SG) 2016-04-13 — — EP claimed
WO-2014196930-A1 SPIRO-1,1'-BIINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALLADIUM-CATALYZED ASYMMETRIC HECK REACTION NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2014-12-11 — — WO claimed
US-20020165411-A1 Sterically hindered phosphine ligands and uses thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-11-07 — — US claimed
WO-2002048160-A1 STERICALLY HINDERED PHOSPHINE LIGANDS AND USES THEREOF YALE UNIVERSITY (US) 2002-06-20 — — WO claimed
CN-122070289-A Hydroxynorketamine analogues and uses thereof 灵飞制药公司 2026-05-19 — — CN disclosed
US-12600698-B2 Kinase inhibitors VIDYA THERAPEUTICS, INC. (US) 2026-04-14 — — US disclosed
US-12351924-B2 Electroreductive cross coupling OHIO STATE INNOVATION FOUNDATION (US) 2025-07-08 — — US disclosed
EP-4568948-A1 COMPOUNDS FOR TREATING CANCER Genesis Therapeutics, Inc. (US) 2025-06-18 — — EP disclosed
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 — — US disclosed
US-20250066350-A1 AROMATIC HETEROCYCLE-SUBSTITUTED COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF INNOVSTONE THERAPEUTICS LIMITED (CN) 2025-02-27 — — US disclosed
CN-119143753-A Salt of heterocyclic antitumor compound and crystal form thereof 石药集团中奇制药技术（石家庄）有限公司 2024-12-17 — — CN disclosed
WO-1993019749-A1 COMPOUNDS USEFUL FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES SMITHKLINE BEECHAM CORPORATION (US) 1993-10-14 — — WO disclosed
US-5245027-A 3-FLUOROSULFONYLOXYCEPH-3-EM COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 1993-09-14 — — US disclosed
WO-1993016997-A1 2,3,4,5-TETRAHYDRO-1H^_-3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF α-SUBSTITUTED-ARYLACETAMIDES SCHERING CORPORATION (US) 1993-09-02 — — WO disclosed
US-5241065-A Selectively antagonize dopamine D-1 receptors SCHERING CORPORATION (US) 1993-08-31 — — US disclosed
US-5223526-A For plants MONSANTO COMPANY (US) 1993-06-29 — — US disclosed
WO-1993011117-A1 PYRAZOLE CARBOXANILIDE FUNGICIDES MONSANTO COMPANY (US) 1993-06-10 — — WO disclosed
EP-0431794-A2 3-Fluorosulfonyloxyceph-3-EM displacement process Bristol-Myers Squibb Company (US) 1991-06-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066350-A1 AROMATIC HETEROCYCLE-SUBSTITUTED COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF ATR, WEE1, WEE2 HDAC4 1237/4885HDAC2 724/4885HDAC8 236/4885
US-20160136629-A1 SPIRO-1,1'-BINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALADIUM-CATALYZED ASYMMETRIC HECK REACTION SBK1, SIK1, PDPK1 HDAC4 1051/4885HDAC2 666/4885HDAC8 787/4885
US-12600698-B2 Kinase inhibitors BTK, BMX, GSK3B HDAC4 3391/4885HDAC2 1755/4885HDAC8 2539/4885
US-20020165411-A1 Sterically hindered phosphine ligands and uses thereof NRP1, NR2C2, CXCR1 HDAC4 4657/4885HDAC2 3261/4885HDAC8 4132/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 HDAC4 2788/4885HDAC2 1831/4885HDAC8 2722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.