Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19525077 | 0.81 | RECQL (0.35) | RECQLGLASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5175953 | 0.70 | MGLL (0.46) | GLASMN1; SMN2ALDH1A1KDM4EMGLL | |
| SCHEMBL29194966 | 0.66 | MGLL (0.41) | RECQLGLASMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL11044755 | 0.66 | MGLL (0.50) | GLASMN1; SMN2ALDH1A1KDM4EMGLL | |
| SCHEMBL10560780 | 0.64 | MGLL (0.48) | GLASMN1; SMN2ALDH1A1KDM4EMGLL | |
| SCHEMBL30709623 | 0.64 | MGLL (0.48) | GLASMN1; SMN2ALDH1A1KDM4EMGLL | |
| SCHEMBL23673842 | 0.64 | ALDH1A1 (0.52) | RECQLGLASMN1; SMN2ALDH1A1BLM | |
| SCHEMBL27924627 | 0.63 | MGLL (0.46) | ALDH1A1KDM4EMGLLHPGD | |
| SCHEMBL29141222 | 0.63 | MGLL (0.46) | SMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL3452606 | 0.62 | MGLL (0.41) | SMN1; SMN2ALDH1A1KDM4EMGLLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321257-A1 | SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2018-05-16 | — | — | EP | disclosed |