Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608448 | 0.78 | CXCR3 (0.58) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL10916900 | 0.73 | CXCR3 (0.53) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL12453094 | 0.71 | CXCR3 (0.55) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL23348211 | 0.70 | CXCR3 (0.50) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL18773758 | 0.68 | CXCR3 (0.47) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL4735406 | 0.68 | — | — | |
| SCHEMBL8462280 | 0.68 | CXCR3 (0.46) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL9175183 | 0.68 | CXCR3 (0.46) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL9175194 | 0.68 | CXCR3 (0.46) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM | |
| SCHEMBL8462281 | 0.68 | CXCR3 (0.46) | CXCR3SMN1; SMN2ALOX15ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |