Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 9/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25479477 | 0.79 | CXCR3 (0.42) | CXCR3CARM1PRMT6PRMT8ALDH1A1 | |
| SCHEMBL7608448 | 0.78 | CXCR3 (0.58) | CXCR3ALDH1A1ALOX15SMN1; SMN2PKM | |
| SCHEMBL10916900 | 0.73 | CXCR3 (0.53) | CXCR3ALDH1A1ALOX15SMN1; SMN2PKM | |
| SCHEMBL20144882 | 0.71 | CXCR3 (0.51) | CXCR3ALDH1A1ALOX15SMN1; SMN2PKM | |
| SCHEMBL23348211 | 0.70 | CXCR3 (0.50) | CXCR3ALDH1A1ALOX15SMN1; SMN2PKM | |
| SCHEMBL132152 | 0.70 | — | — | |
| SCHEMBL10267683 | 0.69 | ALDH1A1 (0.47) | CXCR3ALDH1A1ALOX15SMN1; SMN2PKM | |
| SCHEMBL1965488 | 0.69 | — | — | |
| Ammonia Solution, Strong SCHEMBL6793670 | 0.69 | ALDH1A1 (0.46) | ALDH1A1ALOX15SMN1; SMN2PKM | |
| Bromide SCHEMBL31267150 | 0.69 | ALDH1A1 (0.46) | ALDH1A1ALOX15SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121683-B1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-08-31 | — | — | EP | disclosed |