SCHEMBL2014489

SCHEMBL2014489

CCOc1cc(C(=O)N(C)C(CCNC(=O)c2cc(C)nn2CC)Cc2ccccc2)cc(C)n1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.61
HCRTR2 O43614 2/20 0.61
MAPT P10636 1/20 0.40
STING1 Q86WV6 12/20 0.38
KLKB1 P03952 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP1A2 P05177 1/20 0.37
GLA P06280 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
SMYD3 Q9H7B4 2/20 0.37
IRF3 Q14653 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2054242 1.00 HCRTR1 (0.61) HCRTR1HCRTR2MAPTSTING1KLKB1
SCHEMBL2014557 0.93 HCRTR1 (0.62) HCRTR1HCRTR2STING1SMYD3IRF3
SCHEMBL2011420 0.90 HCRTR1 (0.65) HCRTR1HCRTR2STING1SMYD3IRF3
SCHEMBL6919382 0.88 HCRTR1 (0.72) HCRTR1HCRTR2MAPTKLKB1ALDH1A1
SCHEMBL2010949 0.88 HCRTR1 (0.72) HCRTR1HCRTR2MAPTKLKB1ALDH1A1
SCHEMBL2012845 0.88 HCRTR1 (0.64) HCRTR1HCRTR2STING1L3MBTL1SMYD3
SCHEMBL2053609 0.88 HCRTR1 (0.64) HCRTR1HCRTR2STING1L3MBTL1SMYD3
SCHEMBL2013557 0.85 HCRTR1 (0.64) HCRTR1HCRTR2MAPTSTING1L3MBTL1
SCHEMBL2011853 0.81 HCRTR1 (0.59) HCRTR1HCRTR2MAPTSTING1ALDH1A1
SCHEMBL2014566 0.80 HCRTR1 (0.64) HCRTR1HCRTR2MAPTSTING1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed