Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 6/20 | 0.67 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.67 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145234 | 1.00 | HCRTR2 (0.67) | HCRTR2HCRTR1CCNKCCNA2CDK2 | |
| SCHEMBL20144784 | 0.86 | HCRTR2 (0.69) | HCRTR2HCRTR1HTTLMNASMN1; SMN2 | |
| SCHEMBL18697642 | 0.86 | HCRTR2 (0.69) | HCRTR2HCRTR1HTTLMNASMN1; SMN2 | |
| SCHEMBL20144897 | 0.84 | HCRTR2 (0.68) | HCRTR2HCRTR1CCNKCCNA2CDK2 | |
| SCHEMBL16032435 | 0.80 | HCRTR2 (1.00) | HCRTR2HCRTR1TSHRMEN1KMT2A | |
| SCHEMBL16032973 | 0.80 | HCRTR2 (1.00) | HCRTR2HCRTR1TSHRMEN1KMT2A | |
| SCHEMBL16078132 | 0.80 | HCRTR2 (1.00) | HCRTR2HCRTR1TSHRMEN1KMT2A | |
| SCHEMBL20144887 | 0.80 | HCRTR2 (1.00) | HCRTR2HCRTR1TSHRMEN1KMT2A | |
| SCHEMBL20145172 | 0.80 | HCRTR2 (0.46) | HCRTR2HCRTR1NPSR1TSHRMEN1 | |
| SCHEMBL20145110 | 0.80 | HCRTR2 (0.66) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |