Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.75 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.75 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.75 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.75 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.75 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.75 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.75 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724766 | 0.89 | ACHE (0.86) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2246410 | 0.88 | ACHE (0.88) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL16387807 | 0.85 | ACHE (0.69) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL7137991 | 0.83 | ACHE (0.84) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2188478 | 0.83 | ACHE (0.84) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2188030 | 0.81 | ACHE (0.76) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2189750 | 0.80 | ACHE (0.79) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL7134093 | 0.77 | ACHE (0.73) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2192272 | 0.75 | ACHE (0.70) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL168487 | 0.75 | ACHE (0.70) | ACHEGRIN1GRIN2AGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013824-B1 | CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ALZPROTECT (FR) | 2018-05-16 | — | — | EP | disclosed |