Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.79 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.79 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.79 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.79 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.79 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.79 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.79 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188478 | 0.93 | ACHE (0.84) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL3724766 | 0.86 | ACHE (0.86) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2188030 | 0.85 | ACHE (0.76) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL7137991 | 0.85 | ACHE (0.84) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2246410 | 0.85 | ACHE (0.88) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL7134093 | 0.82 | ACHE (0.73) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL168487 | 0.81 | ACHE (0.70) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL2192272 | 0.81 | ACHE (0.70) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| Dehydrostobadine SCHEMBL167500 | 0.81 | L3MBTL1 (0.97) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| Dehydrostobadine SCHEMBL29468212 | 0.81 | L3MBTL1 (0.97) | ACHEGRIN1GRIN2AGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458155-B2 | Pyrido[4,3-b]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150051218-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. | 2015-02-19 | — | — | US | disclosed |
| US-8907097-B2 | Pyrido[4,3-b]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906925-B2 | Pyrido[4,3-B]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20130190322-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2346332-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | Medivation Technologies, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| US-20100216814-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. | 2010-08-26 | — | — | US | disclosed |
| WO-2010051501-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051218-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | ACHE 118/4885GRIN1 95/4885GRIN2A 27/4885 |
| US-20130190322-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | ACHE 118/4885GRIN1 95/4885GRIN2A 27/4885 |
| US-20100216814-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | ACHE 118/4885GRIN1 95/4885GRIN2A 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.