Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.47 |
| ▸ | FEN1 | P39748 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145647 | 0.81 | MAPK1 (0.49) | MAPK1ALOX5APFEN1MAP4K4BMPR1B | |
| SCHEMBL16679074 | 0.78 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL16679072 | 0.78 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL19053705 | 0.74 | MAPK1 (0.66) | MAPK1 | |
| SCHEMBL19947436 | 0.73 | RIPK2 (0.54) | — | |
| SCHEMBL19947423 | 0.73 | MAPK14 (0.55) | ROCK2 | |
| SCHEMBL19029542 | 0.71 | CD38 (0.50) | ROCK2 | |
| SCHEMBL31377858 | 0.70 | ABL1 (0.48) | ROCK2 | |
| SCHEMBL12078314 | 0.70 | CHEK2 (0.67) | FYNMAP4K4LRRK2 | |
| SCHEMBL31377884 | 0.70 | ROCK2 (0.51) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |