Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270258 | 1.00 | ALOX5 (0.49) | ALOX5SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL22240437 | 1.00 | ALOX5 (0.49) | ALOX5SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL10137636 | 0.83 | ALOX5 (0.50) | ALOX5KDM4EALDH1A1POLBLMNA | |
| SCHEMBL4431627 | 0.83 | ALOX5 (0.50) | ALOX5KDM4EALDH1A1POLBLMNA | |
| SCHEMBL4431629 | 0.83 | ALOX5 (0.50) | ALOX5KDM4EALDH1A1POLBLMNA | |
| SCHEMBL30782219 | 0.83 | ALOX5 (0.50) | ALOX5KDM4EALDH1A1POLBLMNA | |
| SCHEMBL20053566 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1LMNATDP1NPC1 | |
| SCHEMBL6353091 | 0.79 | ALOX5 (0.47) | ALOX5KDM4EALDH1A1POLBLMNA | |
| SCHEMBL6353089 | 0.79 | ALOX5 (0.47) | ALOX5KDM4EALDH1A1POLBLMNA | |
| SCHEMBL15420512 | 0.79 | ALOX5 (0.47) | ALOX5KDM4EALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10618887-B2 | Pyrimidinyl tyrosine kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2020-04-14 | — | — | US | disclosed |
| US-20190047986-A1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2019-02-14 | — | — | US | disclosed |
| EP-2858499-B1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | BIOGEN MA INC (US) | 2018-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047986-A1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | ABL1, BTK, ABL2 | ALOX5 4234/4885SLC6A2 3363/4885SLC6A4 3909/4885 |
| US-10618887-B2 | Pyrimidinyl tyrosine kinase inhibitors | ABL1, BTK, ABL2 | ALOX5 4234/4885SLC6A2 3363/4885SLC6A4 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.