Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19724966 | 0.84 | HTT (0.48) | JAK3KDM4EALDH1A1HTTLMNA | |
| SCHEMBL10077250 | 0.79 | HTT (0.45) | JAK3KDM4EALDH1A1HTTLMNA | |
| SCHEMBL20862666 | 0.78 | JAK3 (0.55) | JAK3KDM4EMAP4K4HTTTP53 | |
| SCHEMBL20862642 | 0.78 | JAK3 (0.55) | JAK3KDM4EMAP4K4HTTTP53 | |
| SCHEMBL4389982 | 0.78 | ALDH1A1 (0.57) | JAK3KDM4EGAAALDH1A1MAP4K4 | |
| SCHEMBL20862434 | 0.77 | MAP4K4 (0.48) | RPS6KB1KDM4EGAAMAP4K4 | |
| SCHEMBL1627372 | 0.77 | HTT (0.43) | JAK3KDM4EALDH1A1HTTLMNA | |
| SCHEMBL19801719 | 0.76 | RPS6KB1 (0.42) | RPS6KB1KDM4EGAAAKT2 | |
| SCHEMBL9159049 | 0.76 | HTT (0.61) | JAK3KDM4EGAAALDH1A1HTT | |
| SCHEMBL19719450 | 0.76 | HTT (0.52) | JAK3KDM4EALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3461824-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Biogen MA Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-2858499-B1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | BIOGEN MA INC (US) | 2018-05-16 | — | — | EP | disclosed |