Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858687 | 0.86 | LMNA (0.54) | LMNAMTNR1AMTNR1BCASP2HDAC3 | |
| SCHEMBL15621584 | 0.82 | LMNA (0.56) | LMNAMTNR1AMTNR1BCASP2HDAC3 | |
| SCHEMBL18418129 | 0.81 | CACNA1H (0.38) | LMNACHRM5CHRM1CHRM3KDM4E | |
| SCHEMBL7399780 | 0.79 | NPSR1 (0.41) | MTNR1AMTNR1BTDP1MAPK1HTT | |
| SCHEMBL22236819 | 0.79 | NPFFR1 (0.48) | KDM4EALDH1A1 | |
| SCHEMBL18463960 | 0.77 | MAPK1 (0.35) | MAPK1HTT | |
| SCHEMBL8470823 | 0.77 | ALDH1A1 (0.39) | TDP1MAPK1ALDH1A1HTT | |
| SCHEMBL9036317 | 0.74 | NPSR1 (0.34) | MAPK1HTT | |
| SCHEMBL21639882 | 0.74 | LMNA (0.46) | LMNAMTNR1AMTNR1BCASP2HDAC3 | |
| SCHEMBL8589603 | 0.73 | NPSR1 (0.36) | MTNR1AMTNR1BTDP1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |