Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 12/20 | 0.52 |
| ▸ | EIF4E | P06730 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19243715 | 0.85 | MKNK1 (0.66) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL20146864 | 0.85 | MKNK1 (0.66) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL15288936 | 0.81 | MKNK1 (0.75) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL18609486 | 0.79 | MKNK1 (0.57) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL20418033 | 0.78 | MKNK1 (0.71) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL19243847 | 0.75 | MKNK1 (0.55) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL15288596 | 0.73 | MKNK1 (0.76) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL20146865 | 0.73 | MKNK1 (0.44) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL19243768 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL16304120 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2EIF4ECYP3A4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |