SCHEMBL20147010

SCHEMBL20147010

Cc1ccc(-c2sc(-c3ccc(-c4cccs4)s3)cc2C2=C(c3cc(-c4ccc(-c5cccs5)s4)sc3-c3ccc(C)s3)C(F)(F)C(I)(I)C2(F)F)s1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.33
ALDH1A1 P00352 3/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MEN1 O00255 1/20 0.32
HPGD P15428 1/20 0.32
KMT2A Q03164 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
LTA4H P09960 1/20 0.31
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
PIM1 P11309 1/20 0.30
PIM3 Q86V86 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14838420 0.91 DPP4 (0.35) DPP4ALDH1A1KDM4ELMNAGLA
SCHEMBL14838258 0.88 ALDH1A1 (0.34) DPP4ALDH1A1KDM4ELMNAGLA
SCHEMBL16011183 0.87 ALDH1A1 (0.35) DPP4ALDH1A1KDM4ELMNAGLA
SCHEMBL20147011 0.85 DPP4 (0.32) DPP4ALDH1A1KDM4ELMNAGLA
SCHEMBL21695435 0.80 MEN1 (0.32) ALDH1A1KDM4ELMNAGLAGAA
SCHEMBL16021800 0.80 DPP4 (0.39) DPP4ALDH1A1KDM4ELMNAGLA
SCHEMBL14838349 0.80
SCHEMBL16021785 0.80 PDK2 (0.31) ALDH1A1MEN1HPGDKMT2ANPSR1
SCHEMBL16243802 0.79 ALDH1A1 (0.38) DPP4ALDH1A1KDM4ELMNAGLA
SCHEMBL14838326 0.78 NPC1 (0.30) ALDH1A1MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2760969-B1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MAT INC (CA) 2018-05-16 EP disclosed