Sugi Predict

Sugi Predict / Compounds / SCHEMBL14838420

SCHEMBL14838420

SCHEMBL14838420

Cc1ccc(-c2sc(-c3ccc(-c4cccs4)s3)cc2C2=C(c3cc(-c4ccc(-c5cccs5)s4)sc3-c3ccc(C)s3)C(F)(F)C(F)(F)C2(F)F)s1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 4/20 0.35
▸ ALDH1A1 P00352 4/20 0.33
▸ KDM4E B2RXH2 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ GAA P10253 2/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ GLA P06280 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ HPGD P15428 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ LTA4H P09960 1/20 0.32
▸ NPC1 O15118 2/20 0.31
▸ RAB9A P51151 2/20 0.31
▸ PIM1 P11309 1/20 0.31
▸ PIM3 Q86V86 1/20 0.31
▸ PGR P06401 1/20 0.30
▸ TP53 P04637 1/20 0.30
▸ POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14838258 0.97 ALDH1A1 (0.34) DPP4ALDH1A1KDM4ELMNAGAA
SCHEMBL16011183 0.96 ALDH1A1 (0.35) DPP4ALDH1A1KDM4ELMNAGAA
SCHEMBL20147010 0.91 DPP4 (0.33) DPP4ALDH1A1KDM4ELMNAGAA
SCHEMBL20147011 0.90 DPP4 (0.32) DPP4ALDH1A1KDM4ELMNAGAA
SCHEMBL16021800 0.90 DPP4 (0.39) DPP4ALDH1A1KDM4ELMNAGAA
SCHEMBL14838349 0.90 — —
SCHEMBL21695435 0.89 MEN1 (0.32) ALDH1A1KDM4ELMNAGAAL3MBTL1
SCHEMBL16021785 0.89 PDK2 (0.31) ALDH1A1MEN1HPGDKMT2ANPSR1
SCHEMBL14838326 0.88 NPC1 (0.30) ALDH1A1MAPTNPC1HSD17B10
SCHEMBL16011298 0.86 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11124524-B2 Diarylethene compounds and uses thereof SOLUTIA CANADA INC. (US) 2021-09-21 — — US disclosed
US-10556912-B2 Diarylethene compounds and uses thereof SWITCH MATERIALS, INC. (CA) 2020-02-11 — — US disclosed
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2019-08-22 — — US disclosed
US-20160083398-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2016-03-24 — — US disclosed
US-20160083398-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2016-03-24 — — US disclosed
WO-2013044371-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLCYCLOPENTENE DERIVATIVES AS OPTICAL FILTERS SWITCH MATERIALS, INC. (CA) 2013-04-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF KCNH2, KCNH3, SCN2B DPP4 4383/4885ALDH1A1 1014/4885KDM4E 1996/4885
US-10556912-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B DPP4 4383/4885ALDH1A1 1014/4885KDM4E 1996/4885
US-11124524-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B DPP4 4383/4885ALDH1A1 1014/4885KDM4E 1996/4885
US-20160083398-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF KCNH2, KCNH3, SCN2B DPP4 4383/4885ALDH1A1 1014/4885KDM4E 1996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.