Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147475 | 0.83 | CCR1 (0.34) | SIGMAR1DPP4MMP1MMP9MMP13 | |
| SCHEMBL20147467 | 0.82 | TP53 (0.38) | SIGMAR1DPP4MMP1MMP9MMP13 | |
| SCHEMBL20147372 | 0.79 | HRH3 (0.34) | SIGMAR1DPP4MMP1MMP9MMP13 | |
| SCHEMBL20147471 | 0.79 | SIGMAR1 (0.37) | SIGMAR1DPP4MMP1MMP9MMP13 | |
| SCHEMBL20147364 | 0.79 | MEN1 (0.49) | HRH3L3MBTL1 | |
| SCHEMBL20147473 | 0.78 | SIGMAR1 (0.33) | SIGMAR1DPP4MMP9MMP13 | |
| SCHEMBL20147353 | 0.78 | PIK3CD (0.40) | SIGMAR1DPP4HRH3CYP2D6 | |
| SCHEMBL20069718 | 0.78 | EPHX1 (0.39) | SIGMAR1HRH3CYP2D6ALDH1A1 | |
| SCHEMBL16304087 | 0.78 | DRD2 (0.37) | MMP1MMP9MMP13HRH3CYP2D6 | |
| SCHEMBL20147371 | 0.77 | SIGMAR1 (0.47) | SIGMAR1HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | SIGMAR1 3807/4885DPP4 1963/4885MMP1 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.