⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147326 | 0.82 | SIGMAR1 (0.36) | — | |
| SCHEMBL20147370 | 0.77 | HRH3 (0.35) | — | |
| SCHEMBL20147342 | 0.76 | BIRC2 (0.37) | — | |
| SCHEMBL20148021 | 0.74 | RET (0.45) | — | |
| SCHEMBL20147314 | 0.74 | HSD11B1 (0.35) | — | |
| SCHEMBL20147368 | 0.74 | CYP2D6 (0.33) | — | |
| SCHEMBL20147320 | 0.73 | SETD7 (0.36) | — | |
| SCHEMBL20147319 | 0.73 | CYP2D6 (0.35) | — | |
| SCHEMBL20147313 | 0.73 | CYP2D6 (0.35) | — | |
| SCHEMBL20147498 | 0.73 | RET (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |