Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 8/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16224518 | 0.79 | MAP3K12 (0.33) | MAP3K12 | |
| SCHEMBL1317475 | 0.78 | AURKA (0.41) | MTORPIK3CAAURKAPDPK1PIK3R1 | |
| SCHEMBL1319437 | 0.77 | CYP1A2 (0.56) | MTORPIK3CAAURKAPDPK1PIK3R1 | |
| SCHEMBL20147760 | 0.73 | MAP3K12 (0.67) | MAP3K12 | |
| SCHEMBL20147735 | 0.73 | AURKA (0.40) | MTORPIK3CAAURKAPDPK1PIK3R1 | |
| SCHEMBL17510255 | 0.72 | MAP3K12 (0.56) | MAP3K12 | |
| SCHEMBL22775348 | 0.71 | AURKA (0.41) | MTORPIK3CAAURKAPDPK1PIK3R1 | |
| SCHEMBL22775349 | 0.71 | AURKA (0.41) | MTORPIK3CAAURKAPDPK1PIK3R1 | |
| SCHEMBL21061931 | 0.70 | ATR (0.41) | MTORPIK3CAAURKAPDPK1PIK3R1 | |
| SCHEMBL21061930 | 0.70 | ATR (0.41) | MTORPIK3CAAURKAPDPK1PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133219-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133219-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | BCHE, SNCA, HAX1 | MTOR 3221/4885PIK3CA 3863/4885AURKA 2716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.